| Seizure Risk Tramadol causes seizures in animal models, and a few seizures have been reported in humans receiving excessive single oral doses (700 mg) or large intravenous doses (300 mg). Administration of Ultram may enhance the seizure risk in patients taking MAO inhibitors, neuroleptics, other drugs that reduce the seizure threshold patients with epilepsy, or patients otherwise at increased risk for seizure. In animal studies, naloxone administration increased the risk of convulsions. |
| Use with CNS Depressants Ultram should be used with caution and in reduced dosages when administered to patients receiving CNS depressants such as alcohol, opioids, anesthetic agents, phenothiazines, tranquilizers or sedative hypnotics. |
| Use with MAO Inhibitors Ultram should be used with great caution in patients taking monoamine oxidase inhibitors, since tramadol inhibits the uptake of norepinephrine and serotonin. |